The Food and Drug Administration took a highly unusual step this week: It acknowledged that a widely used generic drug -- a copycat of the antidepressant Wellbutrin XL -- was not the equivalent of the original drug produced by GlaxoSmithKline since 2003. (Snip) In recent years, a number of pharmacologists have raised concerns about the FDA's standards for approving a range of generic medications -- concerns that the agency has turned away with the unbending assertion that all generics on the market are "the same as those brand-name drugs in dosage form, safety, strength, route of administration, quality,
Comments: The article point seems to be that our FDA is not doing ''due diligence'' when allowing some drug company to come in and claim that their drug is exactly what the major pharmaceutical company invented, ran clinical trials, and then massed marked for ''obscene profits.'' We all know that even our own doctors & health care plans turn US consumers to use generics in the case of keeping prices down. Even our pharmacies are geared to sell this cheaper [knock-off] version in an attempt to keep our business, in the larger store it is usually housed [like Wal-Mart].
Lets see. The pull the generic ones off the shelves. Forcing us to pay more for name brand, but then the name brand companies gets sued for millions if anything happens to the patients. Then they have to pull theirs off too. Pretty soon, we won't have any meds left to take. We've got way too many laws that we need to get rid of.
This is an important article. Whether you post a Reply or not you should read it.
A family member is now on generic Lexapro and seems to be doing fine. But any change from the present manufacturer of that generic will be closely watched. All generics of the same drug are not created equal.
Our family has had excellent results with generics from Teva. My husband's generic simvastatin was switched to a company called Lupin, located in Goa. He had side effects which were noticeable. I got the pharmacy and our health insurance to get him on Teva's generic and he is back to doing well.
Generics do not have to exactly match the original formulation as to its active ingredient(s). I remember seeing a percentage of variation that was FDA-acceptable. The inactive ingredients - those ingredients that deliver the active ingredient(s) - are often a problem to some users.
My doctors will not permit anything but the original brand when hormones of any kind are involved because even a tiny variation can be too much in something like thyroid supplementation, for example.
We must be proactive, paying attention to our reactions to various generic meds which are indeed a bargain if they do not cause their own problems.
The article says but I think should emphasize far more that it did not seem to be a matter of the active ingredient not being right, but that it was not doing the *extended* time-release thing properly.
While that's important, too, it's also fixable, and may be a little more of a quality-control issue than chemical. Anyway I'm always suspicious of time-release pills, something like eating an ice-cream cone might throw off the absorption rate of some drugs.
The FDA is ruthless when it comes to monitoring brand name drug formulations. The generics are a whole other ballgame.
Generics can have a range of drug per pill/capsule different from that listed on the package. (Usually it will be less than the brand name.) Generics can change the dye color of a pill if they wish. No need for them to test whether the dye might interact with the drug and make it less/more potent than the brand name. (Usually it will be less potent.) Generics can have different types of carrier than the brand name version of the drug. That means they may be absorbed faster or slower than the brand name.
And the variables multiply when more than one generic formulation is available from different places. Pharmacies will buy from the company that gives them the best deal, and this may change from month to month. Buyer beware.
Why post this stuf from the LA times. it forces me to pay to read the articles from this paper. I refuse to pay to read the la times article posted here. If i wanted a subscription To the LA times would sign up for it witoput going through lucianne.com
Should a reader have comments about the editorial conduct of this site please address the staff through emails given and not in replies. In this case, it is akin to attacking LCom editorial Staff. LCom Staff.
''All generics of the same drug are not created equal.'' You got that right #2. The generic for Synthroid (hypo thyroid) is certainly not the same. The real thing only costs a little more than the generic.
President Barack Obama is returning to The Tonight Show With Jay Leno. Obama will appear on the Aug. 6 broadcast of NBC´s late-night talker, which would mark his sixth time and the fourth appearance since becoming president. According to NBC, Obama plans to discuss jobs initiatives and the economy during his visit. Previous Tonight Show appearances were Dec. 1, 2006; Oct. 17, 2007; March 19, 2009 — marking the first time a current president appeared on a late-night talker; Oct. 25, 2011; and Oct. 24, 2012. Obama has made the late-night rounds over the years,
An American international politics publication has reported that the US Air Force plans to dispatch fighter jets and tanker aircraft to northern Australia in the next year. Foreign Policy magazine said it was part of a US strategy to dramatically expand its air defence presence across the Pacific and South-East Asia. (Snip) In a breakfast media briefing, he is reported saying the US would send "fighters, tankers and, at some point in the future, maybe bombers on a rotational basis" to Darwin. General Carlisle is reported to have said the aircraft would initially go to the RAAF base in Darwin
Most fishermen are guilty of the odd photobrag, but none can match this bloke´s cockiness. The Victorian fisherman celebrated catching a huge shark by climbing inside the gutted fish, poking his arm through its gills and posing for a joke shot with his knife buried between its eyes. In a world where every angler is pictured next to his prize catch with a thumbs up, it´s becoming increasingly difficult for intrepid fishermen to stand out. But this guy - let´s call him the Shark Slayer - certainly managed it. ´Arch´, who works at the Metung Hotel in Gippsland, was present when the photo was taken.
Washington - U.S. spy agencies plan to release newly declassified documents as early as this week about the National Security Agency surveillance programs revealed by former contractor Edward Snowden, and also material related to a secret intelligence court, a U.S. intelligence official said on Tuesday. (Snip) The documents would also include information about the Foreign Intelligence Surveillance Court, the official said. That court operates in secrecy in making decisions on government surveillance requests. The Washington Post reported late Tuesday that senior U.S. officials said one of the orders
Washington - President Barack Obama has asked two senior Republican senators to travel to Egypt to meet with its military leaders and the opposition, as Cairo´s allies struggle with how to address the turmoil convulsing the country. (Snip) U.S. officials have been grappling with how to respond to the situation in Egypt since its elected Islamist president, Mohamed Mursi, was ousted by the military on July 3. In particular, they have struggled with how to handle the $1.55 billion in mostly military aid Washington sends to Cairo each year. Egypt has long been an important U.S. ally
In a significant victory for law enforcement, a federal appeals court on Tuesday said that government authorities could extract historical location data directly from telecommunications carriers without a search warrant. The closely watched case, in the United States Court of Appeals for the Fifth Circuit, is the first ruling that squarely addresses the constitutionality of warrantless searches of historical location data stored by cellphone service providers. Ruling 2 to 1, the court said a warrantless search was “not per se unconstitutional” because location data was “clearly a business record”
Washington - Secretary of State John Kerry said Tuesday that Israeli and Palestinian negotiators would convene again in the Middle East within two weeks and that their goal would be to work out a comprehensive peace agreement within nine months that would lead to an independent Palestinian state. (Snip) “Our objective will be to achieve a final status agreement over the course of the next nine months,” Mr. Kerry said. “We all understand the goal that we’re working towards: two states living side by side in peace and security.” As they resume peace talks that have been moribund since 2010,
Three former high-ranking Penn State officials, including the university’s former president, Graham B. Spanier, were ordered Tuesday to stand trial on charges that they were part of a cover-up related to the child sexual abuse scandal involving the former football coach Jerry Sandusky. After a two-day preliminary hearing this week, Harrisburg District Judge William Werner decided there was enough evidence against Spanier, the retired university vice president Gary Schultz and the former athletic director Tim Curley to proceed with a trial, which could start later this year.
Anti-Christian extremist groups like the ACLU, the Freedom From Religion Foundation and People for the American Way hate God. They also hate America. True America. These "progressive" outfits - along with like-minded politicos, judges, Hollywood elitists and left-wing media-types - hate that this great nation was expressly founded upon the bedrock precepts of the Judeo-Christian tradition. And so, in response, they lash out. They endeavor first to raze our God-blessed America, and then raise, from the rubble, a godless America fashioned in their own secular-socialist self-image.
Last week, Utah Sen. Mike Lee (R.) sent a letter to Senate Majority Leader Harry Reid (D., Nev.), “informing Senator Reid that we will not vote for a continuing resolution that funds Obamacare,” risking a government shutdown if Lee’s objectives are not achieved. While eleven other Senate Republicans have signed on to Lee’s letter, other Republicans are denouncing the move in surprisingly direct language. “It’s not an achievable strategy…and it’s dishonest,” said Sen. Tom Coburn (R., Okla.). “It’s the dumbest idea I’ve ever heard of,” added Sen. Richard Burr (R., N.C.).
Republican U.S. senators pushed for more transparency on aid to Egypt, if not an outright end to the $1.3 billion per year in military assistance, as U.S. officials struggled on Monday with how to respond to the crisis in Cairo. Senator Rand Paul of Kentucky, a member of the Senate Foreign Relations Committee, has introduced an amendment to a Senate transportation funding bill that would end military aid to Egypt under a U.S. law banning aid to countries that have experienced military coups, and redirect the money to domestic infrastructure projects. Senate aides said on Monday that the bill and Paul's
Sacramento - Gloria Steinem, Jesse Jackson, Bonnie Raitt and Jay Leno have joined prison hunger strikers in calling for an end to California´s use of solitary confinement to control prison gang violence. The civil rights crusaders, singer and late-night comedian are among those who signed a letter sent Monday to Gov. Jerry Brown. The letter calls isolation units "extensions of the same inhumanity practiced at Abu Ghraib and Guantanamo Bay." The letter to Brown, to be followed by a demonstration Tuesday at the Capitol, was arranged by the National Religion Campaign Against Torture and local
There have been days since her son Ezekiel was born 11 months ago that Los Angeles mom Beth Capper has gone without food to keep up her supply. One friend was arrested for stealing some. It´s not drugs or alcohol or even baby formula that has put her in such a bind. It´s diapers. "There´s no way around buying them," said Capper, a 41-year-old single mother who doesn´t work because of a disability. Across the country, mothers like Capper are facing the same predicament. According to a report published Monday in the
It is a small Alaskan village whose inhabitants have relied on the sea for countless generations. But within a decade, it is expected that the ocean which the village of Kivalina has so relied on will completely destroy it--creating America´s first climate change refugees. Temperatures in the Arctic region of Alaska are warming twice as fast as the rest of the U.S, causing ice to retreat, sea levels to rise and coastal erosion to increase. It is a small Alaskan village whose inhabitants have relied on the sea for countless generations. The 400 indigenous Inuit inhabitants of Kivalina, who live
President Obama has been rolling up his sleeves campaigning across the country delivering a surreal stump speech message supposedly aimed at the middle class: big government works, Obamacare is manna from heaven, the wave of recent scandals are “phony” figments of the imagination, and all economic problems are the fault of the Republicans. Conveniently, he leaves out the bankruptcy of Detroit, a city run by his own party for more than half a century. His message is so stale and unconvincing, that even The New York Times and Washington Post have noticed. Both papers, usually loyal to Obama, remarked that
Arizona Sen. John McCain was the Republican Party´s 2008 presidential nominee and he still wants the keys to the Oval Office. But he is beginning to sound more like a fan of likely 2016 Democratic presidential candidate Hillary Clinton. "She´s a rock star," he said in a newly released interview. "She has, maybe not glamour, but certainly the aura of someone widely regarded throughout the world," he added in a reference to her work as secretary of State. McCain, reportedly trying to win back his reputation as a GOP maverick, was asked by the New Republic
FORNEY, Texas - George Zimmerman, the former Florida neighborhood watch leader cleared of all charges in the shooting death of Trayvon Martin, was pulled over for speeding in North Texas on Sunday, CBS DFW reports. According to the station, Zimmerman was armed when officers pulled him over on Highway 80 in Forney, east of Dallas. (Snip) The officer reportedly did not recognize Zimmerman, who was driving a Honda pickup. Zimmerman told the officer he was armed and was then told to put the weapon in his glove compartment, according to the station.
Gotta figure her lead would be even bigger without Joe Miller in the field here. Her nomination for the taking? Alaska should be a top tier pick up opportunity for Senate Republicans next year…but their top choice of a candidate is Sarah Palin. 36% of GOP primary voters in the state say they’d like Palin to be their standard bearer against Mark Begich to 26% for Mead Treadwell, 15% for Dan Sullivan, and 12% for Joe Miller.
Embattled Internal Revenue Service official Lois Lerner and an attorney in the Federal Election Commission’s general counsel’s office appear to have twice colluded to influence the record before the FEC’s vote in the case of a conservative non-profit organization, according to e-mails unearthed by the House Ways and Means Committee and obtained exclusively by National Review Online. The correspondence suggests the discrimination of conservative groups extended beyond the IRS and into the FEC, where an attorney from the agency’s enforcement division in at least one case sought and received tax information about the status of a conservative group,
Sen. John McCain — a Democrat? There was confusion Wednesday after the Arizona Republican mistakenly strolled into President Obama’s meeting with Senate Democrats at the Capitol. The room full of Democrats — who happened to be meeting in the same room where the Senate GOP usually holds their weekly policy luncheons — erupted in applause and laughter as the former Republican presidential candidate made his entrance. As McCain, 76, walked out of the Dem-filled space, reporters pressed him as to why he stepped foot in the room.
In an interview on National Public Radio (NPR), House Minority Leader Nancy Pelosi said her new agenda for women will give mothers access to day care so they can “earn without carrying the burden of child care.” During the interview, aired on Weekend Edition Sunday, Pelosi spoke about her newly announced agenda, which is on her website, and is titled, “When Women Succeed, America Succeeds: An Economic Agenda for Women and Families,” a plan that includes universal pre-school and access to day care for working women, and an increase in the minimum wage.
Karl Rove and more than one hundred Republican donors sent a letter to Republican members of Congress on Tuesday, urging them to pass a comprehensive immigration reform bill that would include, among other provisions, granting "legal status" to illegal aliens who meet certain criteria. Anticipating that lawmakers will face resistance to the bill when they go home for the August recess, the letter marks the escalation of a campaign in which Republican leaders and donors are pressuring House Republicans to act on an immigration reform bill.
I never thought the Trayvon Martin/George Zimmerman case deserved nearly the attention it got. But reasonable people can disagree about that. What strikes me as unconscionable, however, is the way the supposedly objective media have not only sensationalized a tragedy but at times appear to deliberately bend the facts to fit a desired story line. Maybe it started with the use of pictures of a younger Martin or with the sudden embrace of the term "white Hispanic" to describe Zimmerman in order to more easily paint him as a racist. NBC News was the most egregious offender
No matter how much you may hope for it, it seems unlikely that you´ll be using the phrase "Senator Sarah Palin" with any great regularity in 2015. A new poll indicates that the former Alaska governor is about as popular in the state as Barack Obama — which is to say, not very popular at all. But even more surprising, while the former vice presidential candidate has made Alaska a central part of her public image, the state´s residents split on the question of whether Palin is all that Alaskan. Conducted by Public Policy Polling,